In the early 1990ties Ntando Xorile started as a performing artist for the Soweto Dance Project. He worked together with the late artist James Sounders (Cologne), Germaine Agogny (Senegal) as well as Marcio Valeriano (Brazil). In 2006 he joined the Johannesburg Art Bank and exerted great influence on the curatorial direction of the collection. In 2007 Ntando Xorile worked and oversaw together with Clive van der Berg the Spier Contemporary at the Johannesburg Art Gallery.

The same year he became committee member of the Rendezvous Project, which aims to develop relationships between business, education and cultural practitioners. The curator is a member of VANSA (Visual Arts Network South Africa), as well as TRACE, where he is engaged as a researcher and assistant curator. TRACE is a team of professionals in the field of research, exhibition, design and heritage. Currently, Ntando Xorile is co-curatoring CAPE 09 in Cape Town, which presents contemporary cultural practices of present day Africa.